In 1967, Hanna-Barbera produced a cartoon for Anheuser-Busch showing Fred Flintstone and Barney Rubble pushing Busch beer. The ad is said to have been produced for employees of the company and it’s got quite a long and detailed storyline.
Hanna-Barbera also produced a Winston cigarette ad featuring Fred and Barney.
The Flintstones is an American animated sitcom produced by Hanna-Barbera Productions. The series takes place in a romanticized Stone Age setting and follows the activities of the title family, the Flintstones, and their next-door neighbors, the Rubbles (who are also their best friends). It was originally broadcast on ABC from September 30, 1960 to April 1, 1966, and was the first animated series to hold a prime time slot on television.
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